NTS BIENNIAL NTS MEETING. Meeting Contact e-mail ntsmeeting2026@gmail.com

LOCATION: MONTEVIDEO HYATT CENTRIC HOTEL

(https://www.hyatt.com/hyatt-centric/mvdhy-hyatt-centric-montevideo)

WEDNESDAY 21 OCTOBER

15:30-16:30 Registration (credentials) and opening

16:30-17:30 PLENARY LECTURE: VLADIMIR PARPURA

(International Translational Neuroscience Research Institute, Zhejiang Chinese Medical University, Hangzhou, P.R. China): Astrocytes release glutamate by regulated exocytosis in health and malignancy)

17:30-19:15 SYMPOSIUM I: NEURODEVELOPMENTAL CNS DISEASES.

Chair: Marta Antonelli

● Mario Herrera-Marschitz (UChile – Chile): Impaired mitochondrial respiration following perinatal asphyxia in rats assessed with real-time Seahorse technology: reversed by the NAD+ donor nicotinamide riboside.

● Coral Sanfeliu (CSIC – Spain): Prenatal food exposome: Interaction between neurotrophic and neurotoxic factors

● Evan Bordt (Harvard – USA): Maternal autoimmunity and maternal toll-like receptor 7 stimulation and impacts on offspring neurodevelopment.

● Christopher McPherson (National Institute of Environmental Health Sciences –USA):  Identifying key neurodevelopmental processes in a new approach methods battery (NAMs) to efficiently prioritize known developmental neurotoxicants

● Patricia Schuck (UFRJ, Brazil): Galactose neurotoxicity in galactosemia experimental models.

19:15 - 20:30 Welcome cocktail at the hotel rooftop

THURSDAY 22 OCTOBER

9:00 – 10:45 SYMPOSIUM II: AGE - DEPENDENT NEUROTOXICITY I.

Chair: Gustavo Ferreira

● Florencia Arredondo (CUDIM – Uruguay): Neurotoxic mechanisms mediated by aberrant astroglial cells.

● Juan Beaquis (UBA – Argentina): Chronic neuroinflammation in Alzheimer disease preclinical models

● Andrea Paula Lima (University of Chile - Chile): The Janus face of calcium and ROS: from synaptic plasticity to neurodegeneration in Alzheimer’s Disease.

● Italo Mocchetti (Georgetown Univ - USA): Role of amyloid beta in HIV induced neurotoxicity

10:45 – 11:15 Coffee break

11:15 – 12:45 SYMPOSIUM III: AGE - DEPENDENT NEUROTOXICITY II.

Chair: Rita Raisman-Vozari

● Rosario Moratalla Villalba (Cajal Institute – Spain): Beyond motor symptoms: hidden molecular mechanisms in Parkinson’s disease

● Miriam Beatriz Virgolini (UNC – Argentina): Pesticides, redox imbalance, and dopaminergic vulnerability: mechanistic insights into parkinsonism

● Elaine Aparecida Del Bel (USP – Brazil): TRPV1-Ca²⁺-nNOS signaling gates cannabidiol efficacy in L-DOPA-induced dyskinesia

● Jean Harry (NIH – USA): NLRP3 inflammasome activation - so much more than IL-1 release

13:00 – 15:00 Free time for lunch

15:00 – 16:30 SYMPOSIUM IV: NOVEL UNDERLYING MECHANISMS IN NERVOUS SYSTEM DISEASES.

Chair: Silvia Olivera-Bravo

● Gustavo Ferreira (UFRJ - Brazil): Altered astrocyte metabolism in CNS disorders

● Helena Cimarosti (UFSC – Brazil): Sumoylation in neurodegeneration and neuroprotection.

● Henning Ulrich (USP - Brazil): Kinin signaling in neuroprotection and neurodegeneration

● Hercules Freitas (UFRJ – Brazil): Citrate happens: the age-dependent biology of SLC13A5

16:30 – 18:00 Coffee break and posters

18:00 – 19:30 SYMPOSIUM V: CANNABINOIDS AND PSYCHOSTIMULANTS IN CNS.

Chair: Gerardo Romanelli

● Carolina Echeverry (IIBCE – Uruguay): Cannabidiol and related compounds as potential neuroprotectans

2● Francisco Guimarães (USP - Brasil): The multi-target mechanisms of cannabidiol in neuropsychiatric disorders

● Paul Ruiz (UdelaR – Uruguay): Consumption of psychoactive substances in Uruguay

● Giselle Prunell (IIBCE – Uruguay): Molecular signatures of N,N-dimethyltryptamine (DMT) action: linking receptor engagement to structural plasticity.

19:30 – 20:30 EVENING LECTURE: MARÍA TRINIDAD HERRERO (UM - Spain)

Role of the amygdala and chronic stress in neurodegeneration.

FRIDAY 23 OCTOBER

08:30 – 09:30 Plenary Lecture ROMMY VON BERHNARDI  (USACH – Chile):

Aging and neuroinflammation affects microglia-neuron regulation mediated by fractalkine.

Its effects on neuronal function

09:30 – 10:45 SYMPOSIUM VI: NEURON-GLIA INTERACTION IN HEALTH AND DISEASE.

Chair: Silvia Costa

● George Barreto (Limerick – Ireland): Gender and metabolism as critical variables in CNS disorders

● Eugenia Isasi (UdelaR – Uruguay): Neurovascular dysfunction in CNS diseases

● Silvia Olivera-Bravo (IIBCE – Uruguay): Contribution of altered glial phenotypes to neurotoxicity in ALS SOD1G93A rats

● Vedrana Montana (ITNR – China): Two tales of astrocyte pathology: Alzheimer

disease and amyotrophic lateral sclerosis

10:45 – 11:15 Coffee break

11:15 – 12:45 SYMPOSIUM VII: NATURAL PRODUCTS AND NUTRITION AS NEUROPROTECTIVE TOOLS.

Chair: Giselle Prunell

● Silvia Costa Lima (UFBA – Brazil): Recent discoveries related to flavonoids´ neuroprotective actions● Carmen Bolatto (UdelaR – Uruguay): Wine pomace therapy in Drosophila models

of systemic and neural inflammation

● Rita Raisman-Vozari (France): Effects of tetracyclines in experimental models of

neurodegenerative diseases

● Marco Lazo (UA – Ecuador): Foodomics and neuroprotection

13:00 – 15:00 Free time for lunch

315:00 – 16:45 SYMPOSIUM VIII: STATE OF THE ART APPROACHES TO THE CNS

STUDY AND TREATMENT.

Chair: Patricia Schuck

● Gonzalo Jorquera (INTA – Chile): Effects of fecal microbiota transplantation on cognitive functions

● Gerardo Romanelli (IIBCE – Uruguay): Age and sex-dependent effects on the motor unit in a preclinical model of amyotrophic lateral sclerosis

● Alejandra Kun (School of Sciences, IIBCE – Uruguay): In vivo ultrafast Doppler imaging, confocal microscopy and behavioral approaches

● Eliseo Eugenin, Ph.D. (UTMB Texas Univ - USA): Novel mechanisms of NeuroHIV in the aging HIV infected population

16:45 – 19:00 Coffee Break and posters

19:00 – 20:00 CLOSING LECTURE: MICHAEL ASCHNER (Albert Einstein College of Medicine – USA):

From worms to humans: leveraging C. elegans to understand neurotoxic mechanisms

20:00 – 20:15 Closing

20:15 – 22:00 Artistic event and dinner (pre-registration required)

SATELLITE MEETING: SATURDAY 24 - 25 OCTOBER