NTS BIENNIAL NTS MEETING

LOCATION: MONTEVIDEO HYATT CENTRIC HOTEL

(https://www.hyatt.com/hyatt-centric/mvdhy-hyatt-centric-montevideo)

MEETING PROGRAM:

WEDNESDAY 21 OCTOBER

17:00-18:00 Registration (credentials) and opening

18:00-19:00 Plenary Lecture : Astrocytes release glutamate by regulated exocytosis in health and malignancy

• Vladimir Parpura

International Translational Neuroscience Research Institute,

Zhejiang Chinese Medical University, Hangzhou, P.R. China

19:00 - 20:30 Welcome cocktail at the hotel rooftop

THURSDAY 22 OCTOBER

08:00 – 10:00 Symposium I: Neurodevelopmental CNS diseases.

Chair: Marta Antonelli

● Mario Herrera-Marschitz (UChile – Chile): Impaired mitochondrial respiration following perinatal asphyxia in rats assessed with real-time Seahorse technology: reversed by the NAD+ donor nicotinamide riboside.

● Coral Sanfeliu (CSIC – Spain): Prenatal food exposome: Interaction between neurotrophic and neurotoxic factors

● Evan Bordt (Harvard – USA): Maternal autoimmunity and maternal toll-like receptor 7 stimulation and impacts on offspring neurodevelopment.

● Christopher McPherson (National Institute of Environmental Health Sciences – USA): Identifying key neurodevelopmental processes in a new approach methods battery (NAMs) to efficiently prioritize known developmental neurotoxicants

● Patricia Schuck (UFRJ, Brazil): Galactose neurotoxicity in galactosemia experimental models.

10:00 – 10:30 Coffee break

10:30 – 12:00 Symposium IIA: Age-dependent neurotoxicity.

Chair: Gustavo Ferreira

● Andrea Paula Lima (University of Chile - Chile): The Janus face of calcium and ROS:f rom synaptic plasticity to neurodegeneration in Alzheimer’s Disease.

● Florencia Arredondo (CUDIM – Uruguay): Neurotoxic mechanisms mediated by aberrant astroglial cells.

● Gerardo Romanelli (IIBCE – Uruguay): Age and sex-dependent effects on the motor unit in a preclinical model of amyotrophic lateral sclerosis

● Miriam Beatriz Virgolini (UNC – Argentina): Pesticides, redox imbalance, and dopaminergic vulnerability: mechanistic insights into parkinsonism

12:15 – 13:15 Symposium IIB: Age-dependent neurotoxicity.

Chair: Rita Raisman-Vozari

● Rosario Moratalla Villalba (Cajal Institute – Spain): Beyond motor symptoms: hidden molecular mechanisms in Parkinson’s disease

● Jean Harry (NIH – USA): NLRP3 inflammasome activation - so much more than IL-1release

● Eliseo Eugenin (Texas): Novel mechanisms of NeuroHIV in the aging HIV infected population

13:15 – 14:45 Free time for lunch

14:45 – 16:15 Symposium III: Cannabinoids and psychostimulants in CNS.

Chair: GisellePrunell

● Elaine Aparecida Del Bel (USP – Brazil): TRPV1-Ca2+-nNOS signaling gates cannabidiol efficacy in L-DOPA-induced dyskinesia

● Carolina Echeverry (IIBCE – Uruguay): Cannabidiol and related compounds as potential neuroprotectans

● Francisco Guimarães (USP - Brasil): The multi-target mechanisms of cannabidiol in neuropsychiatric disorders

● Paul Ruiz (UdelaR – Uruguay): Consumption of psychoactive substances in Uruguay

16:15 – 18:00 Coffee break and posters

18:00 – 20:00 Symposium IV: Underlying mechanisms in nervous system diseases.

Chair: Silvia Costa

● Gustavo Ferreira (UFRJ - Brazil): Altered astrocyte metabolism in CNS disorders

● Henning Ulrich (USP - Brazil): Kinin signaling in neuroprotection and neurodegeneration

● Helena Cimarosti (UFSC – Brazil): Sumoylation in neurodegeneration and neuroprotection.

● Juan Beaquis (UBA – Argentina): Chronic neuroinflammation in Alzheimer disease preclinical models

● Hercules Freitas (UFRJ – Brazil): Citrate happens: the age-dependent biology ofSLC13A5

20:00 – 21:00 General conference: María Trinidad Herrero (UM - Spain): Role of the amygdala and chronic stress in neurodegeneration.

FRIDAY 23 OCTOBER

08:30 – 10:00 Symposium V: Neuron-glia interaction in health and disease.

Chair: Silvia Costa

● Eugenia Isasi (UdelaR – Uruguay): Neurovascular dysfunction in CNS diseases

● Vedrana Montana (ITNR – China): Two tales of astrocyte pathology: Alzheimer disease and amyotrophic lateral sclerosis

● Silvia Olivera-Bravo (IIBCE – Uruguay): Contribution of altered glial phenotypes to neurotoxicity in ALS SOD1G93A rats

● George Barreto (Limerick – Ireland): Gender and metabolism as critical variables in CNS disorders

10:00 – 10:30 Coffee break

10:30 – 12:00 Symposium VI: Natural products and nutrition as neuroprotective tools.

Chair: Gerardo Romanelli

● Silvia Costa Lima (UFBA – Brazil): Recent discoveries related to flavonoids ́neuroprotective actions

● Carmen Bolatto (UdelaR – Uruguay): Wine pomace therapy in Drosophila models of systemic and neural inflammation

● Giselle Prunell (IIBCE – Uruguay): Psychedelics as neuroprotectants

● Marco Lazo (UA – Ecuador): Foodomics and neuroprotection

12:00 – 14:00 Free time for lunch

14:30 – 15:30 General conference: Rommy von Berhnardi (USACH – Chile): Aging and neuroinflammation affects microglia-neuron regulation mediated by fractalkine. Its effects on neuronal function

15:30 – 16:45 Symposium VII: State of the art approaches to the CNS study and treatment.

Chair: Patricia Schuck

● Gonzalo Jorquera (INTA – Chile): Effects of fecal microbiota transplantation on cognitive functions

● Rita Raisman-Vozari (France): Effects of tetracyclines in experimental models of neurodegenerative diseases

● Alejandra Kun (School of Sciences, IIBCE – Uruguay): In vivo ultrafast Doppler imaging, confocal microscopy and       behavioral approaches

17:00 – 19:00 Coffee Break and posters

19:00 – 20:00 Closing conference: Michael Aschner (Albert Einstein College of Medicine –USA):

20:00 – 20:15 Closing

20:15 – 22:00 Artistic event and Banquet (pre-registration and payment required)